Photo: Winslow Townson / Getty Images Sport / Getty Images
The Boston Celtics square off against the Philadelphia 76ers as 4.5-point favorites in the first game of the 2025-26 NBA season for both teams on Wednesday, October 22, 2025 at 7:30 p.m. ET on NBCS-BOS and NBCS-PH.
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Celtics vs. 76ers Predictions for Wednesday
Our computer projections model for this matchup calls for a final tally of Celtics 122, 76ers 101.
- Moneyline Pick: Celtics (-188)
- Total Pick: Under 229.5 (computer predicts 223.4 points)
- Pick ATS: Celtics (-4.5)
Recent Celtics vs. 76ers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 3/6/2025 | Celtics | -14 | 217.5 | -962 | +627 | 123-105 BOS |
| 2/20/2025 | Celtics | -7 | 225.5 | -296 | +239 | 124-104 BOS |
| 2/2/2025 | Celtics | -12.5 | 224.5 | -680 | +490 | 118-110 BOS |
| 12/25/2024 | Celtics | -9.5 | 221 | -427 | +330 | 118-114 PHI |
Celtics 2024-25 Betting Trends
- Boston covered the spread 39 times in 82 games last season.
- Against the spread, as 4.5-point favorites or greater, the Celtics went 35-37 last season.
- Boston had 37 of its 82 games hit the over last season.
- The Celtics were the moneyline favorite 78 total times last season. They went 60-18 in those games.
- Boston had a record of 55-16 in games it played as a moneyline favorite with odds of -188 or shorter last year (77.5%).
76ers 2024-25 Betting Trends
- Philadelphia put together a 29-53-0 ATS record last season.
- The 76ers' ATS record as underdogs of 4.5 points or greater was 19-21 last year.
- Last season 48 of Philadelphia's games went over the point total.
- The 76ers were underdogs 53 times last season and won 10, or 18.9%, of those games.
- Philadelphia had a record of 7-32, a 17.9% win rate, when it was set as the underdog by +156 or more by bookmakers last season.
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Celtics vs. 76ers Injury Report
Celtics
Celtics:
Jaylen Brown: Questionable (Hamstring),
Jayson Tatum: Out (Achilles)
76ers
76ers:
Trendon Watford: Out (Hamstring),
Paul George: Out (Knee),
Jared McCain: Out (Thumb)
Celtics vs. 76ers Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 7:30 p.m. ET
- TV channel: NBCS-BOS and NBCS-PH
- Location: Boston, Massachusetts
- Arena: TD Garden
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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