The Penn State Nittany Lions (3-2) square off against a fellow Big Ten foe when they host the Northwestern Wildcats (3-2) on Saturday, October 11, 2025 at West Shore Home Field at Beaver Stadium.

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Penn State vs. Northwestern Matchup Info

Game date: Saturday, October 11, 2025
Game time: 3:30 p.m. ET
Location: University Park, Pennsylvania
Venue: West Shore Home Field at Beaver Stadium
TV channel: Fox Sports 1
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Penn State vs. Northwestern Odds and Prediction

Spread favorite: Nittany Lions (-21.5)
Moneyline: Nittany Lions (-1887), Wildcats (+998)
Total: 48 points
Pick ATS: Northwestern (+21.5)
Pick OU: Under (48)
Prediction: Penn State 24, Northwestern 23

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Penn State vs. Northwestern Betting Records and Insights

Penn State is winless against the spread this season (0-5-0).
Northwestern is 3-2-0 ATS this year.
The Nittany Lions have been favored by 21.5 points or more this season four times and failed to cover in all four.
The Wildcats have won their only game this season when playing as at least 21.5-point underdogs.
So far this season, four of Penn State's five games have gone over the point total.
So far this year, two Northwestern games have gone over the point total.

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